The assembly
The manual is well written and comprehensive and also isn’t really required for someone who knows the basics of watercooling as the entire assembly is fairly intuitive.
The assembly wasn’t difficult, but took quite a fair amount of time as there were so many things to do when you are un-mounting and mounting 6 different coolers and have to take the entire system and several peripheral components apart. Plugging the parts in and connecting them up took only minutes. Priming the system also was very easy (I had the radiator and the pump level with each other).
I did notice that the mounting system for the CPU-cooler still has the design-flaw that makes is necessary to remove the motherboard from the case in order to undo the screws that hold the waterblock onto the CPU (at least that how it works on Socket A).
That aside the CPU-cooler is easily mounted and the screws combined with the springs ensure it makes solid contact with the CPUs DIE.

Chipset and CPU-Cooler are assembled

VGA, Chipset and CPU-Cooler all assembled
Now that all the coolers are securely mounted I connect the tubing while the motherboard was not mounted in the case. Doing it this way makes it absolutely impossible for the tubing to be assembled in such a way as to tug on the VGA card or the chipset in any significant way.

Coolers all hooked up
And now I installed the motherboard into the case and hooked up the radiator, reservoir and pump and primed the system.

Everything assembled and ready to go
Priming the system was a simple task; you just have to be ready with the water as the reservoir gets emptied very quickly and if you are too slow then you need to turn the pump off and then on again, otherwise you have to wait for the pump to remove the air.
I left the system running for a couple of hours and could find no leaks. Only the radiator needs some time to expel all the air bubbles, which is not unusual for a multi-channel radiator. If you can wiggle it around a bit while it is priming then you should do so.
Potential difficulties
The immediate problem I faced was getting the pump and reservoir assembly into the case -- and the ChiefTec Dragon "Big-Tower" series is not exactly the world’s smallest case. I will admit there are bigger ones out there but I feel that I have plenty of room.
Unfortunately it is a very tight squeeze getting everything in. The best option is to mount everything above the PSU and have the pump end up lying on its side. As you cannot prime the system with the pump on its side I had to juggle around a bit, priming the system and then turning and positioning the pump and radiator into their final resting place. The ultimate and best solution is to modify the case and if you have the tools, this is without doubt the way to go.